SUPPLEMENTS·LIFE EXTENSION
Life Extension Melatonin 6 Hour Timed Release 300 mcg (100ct)
4.7 · 37 reviews
Editor score8.4/10
Best for: Melatonin-sensitive sleepers, 3 AM wakers, morning-grogginess sufferers
Price
Check price
At Amazon · price changes often, check before buying
Buy at Amazon ↗Updated 2026-08-02
Dose per serving
300 mcg (0.3 mg) melatonin
Release
Timed — gradual over ~6 hours
Count
100 tablets (100 nights at 1/night)
The microdose, stay-asleep melatonin — 300 mcg released over six hours for people whom 5 mg leaves groggy.
Most melatonin on the shelf is 5-10 mg — far above the ~0.3 mg range close to what the body produces nightly. This is the other philosophy: 300 micrograms (0.3 mg) in a vegetarian tablet that dissolves gradually over about six hours, aimed at staying asleep through the night rather than being knocked out at bedtime. $9 for a 100-night supply. If you wake at 3 AM after fast-dissolve melatonin has worn off, or standard doses leave you foggy at breakfast, this is the low-dose experiment worth running first.
Price across 2 retailers
Prices checked 2026-08-02amazon
AmazonBest price✓ Fast delivery · easy returns
300 mcg / 100 tablets listing
Price varies
Prices shown were last checked on 2026-08-02and can change at any time — the price on the retailer's site at checkout is the one that applies. As an Amazon Associate and affiliate we may earn a commission on purchases made through these links, at no extra cost to you.
How our prices work
We show the lowest price we found at our last check (2026-08-02) and the manufacturer's list price for comparison. Retail prices — Amazon's especially — move constantly, so treat these as a guide: the price shown on the retailer's own page at checkout is the one that applies. Tap through to see each retailer's current price.
Should you buy it?
What we like
- Physiological microdose — 300 mcg, not 5,000
- Timed release covers the whole night
- $9 for 100 nights ($0.09/night)
- Vegetarian, gluten-free, non-GMO tablet
What to know before buying
- Deliberately weak — wrong pick for entrenched insomnia
- No USP/NSF third-party certification to cite
- Timed release is slower to start than fast-dissolve for pure sleep-onset trouble
At a glance
Dose per serving300 mcg (0.3 mg) melatonin
ReleaseTimed — gradual over ~6 hours
Count100 tablets (100 nights at 1/night)
FormVegetarian tablet
Gluten-freeYes
Non-GMOYes
CertificationNone (label claims only)
Intended useOccasional sleeplessness (label)
Other doses sold750 mcg and 3 mg versions
Best forStaying asleep, melatonin-sensitive users
How it scores
How our 8.4/10 breaks down — rated on the dimensions that matter most for supplements, from hands-on testing and verified specs, not the marketing.
Evidence
8/10
Dosing
9/10
Purity
7/10
Gentleness
9.5/10
Value
9.5/10
Compare with alternatives
Quick verdicts for the supplements most often considered alongside the Life Extension Melatonin 6 Hour Timed Release 300 mcg (100ct).
VS·HEAD-TO-HEAD
Life Extension Melatonin 6 Hour Timed Release 300 mcg (100ct) vs Nature Made Melatonin 5mg (240ct)
The USP-verified melatonin your GP would actually recommend — same dose as prescription-adjacent formulations at a third of the price.
→ Jet lag recovery, shift workers, occasional sleep onset issues
VS·HEAD-TO-HEAD
Life Extension Melatonin 6 Hour Timed Release 300 mcg (100ct) vs Natrol Melatonin 5mg Fast Dissolve
The fast-dissolve standard — strawberry tablets that melt under the tongue, no water needed, from the #1 melatonin brand.
→ Travel, split-dose flexibility, no-water dosing
VS·HEAD-TO-HEAD
Life Extension Melatonin 6 Hour Timed Release 300 mcg (100ct) vs Vitafusion Max Strength Melatonin 10mg Gummies
The max-dose gummy — 10mg per serving for established high-dose users, from America's biggest gummy-vitamin brand.
→ Established high-dose users, gummy loyalists
Decision support · what no other comparison site has
Take the quiz · 60 secNot sure which one is right for you?
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Frequently asked questions
Why only 300 mcg when gummies are 10 mg?
300 mcg is close to nightly physiological production. Higher doses aren't proportionally more effective for many people and are the usual culprit behind morning grogginess. Low-dose timed-release is the 'start low' option.
Timed release vs fast dissolve — which do I want?
Trouble falling asleep → fast-dissolve (like Natrol) acts quickest. Trouble staying asleep or 3 AM wake-ups → timed release keeps a low level going through the night. Different problems, different formats.
Will 300 mcg feel like anything?
It's deliberately gentle — reviewers with entrenched insomnia often call it insufficient. It suits people who respond to small doses or who get side effects at 5 mg, not people looking for the strongest option.
Is it third-party certified?
No USP or NSF certification — claims are label-only, with the standard FDA disclaimer. If certification matters to you, that's a genuine gap versus some competitors.
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